It refers to neoplastic proliferation of haemopoietic stem cells characterized by accumulation of mature looking lymphocytes in marrow, lymph node, spleen and marked lymphocytosis.
It refers to neoplastic proliferation of haemopoietic stem cells characterized by accumulation of mature looking lymphocytes in marrow, lymph node, spleen and marked lymphocytosis.
Clinical feature:
•Age incidence – 45- 75 years
•Average -55 years
•M: F – 2:1
•Common- Generalised lymph node enlargement
•Anaemia
•Fever, sweat, anorexia
•Less common – Splenomegaly, petechi, infection (RTI) , Bone and joint pain.
Laboratory diagnosis
•1) Blood picture
• a) Hb – Mild to moderate reduce.
• b) WBC –Usually 50000 -200000/ cumm. c) ESR – Markedly increased.
PBF
•RBC – Usually normocytic and normochromic.
•Occasional neucleated cells are seen.
•WBC – Shows marked leucocytosis, 90% are mature lymphocytes and monotonous appearance. Smear cells are also seen.
•Platelet – Initially normal but latter markedly reduce.
BONE MARROW
•Cellularity – Hyper celluler.
•Erythropoiesis – Reduce
•Granulopoiesis – Reduce
•Lymphoiesis - Hyperactive. Most cells are mature looking lymphoid cells. Lymphocytes are more than 30% among all nucleated cells.
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